Table 1.

Enriched gene ontology terms as assessed by gene set enrichment analysis of genes expressed after 1 h of L-lactate treatment.

Gene ontology term	Net enrichment score (NES)	False discovery Rate (FDR)	Leading core genes
Histone acetyltransferase binding	1.92	0.04	Cebpb; Egrl; Zbtb7a; Cited2; Nr4a3
DNA packaging complex	-2.38	0.00	Histlh4m; Hlf0; Hist2h3cl; Hist2h2aal; Histlh2bk; Histlh2bm; Histlh2bp; Hist2h2bb; Hist2h2be; Histlhlc
Protein–DNA complex	-1.99	0.01	Histlh4m; Gins4; Hlf0; Hist2h3cl; Hist2h2aal; Nfe212; Nfya; Nfyb; Poldl; Pole2; Gtf2h3; Terfl; Xpa; Gins2; Hist3h2a; Histlh2bk; Histlh2bm; Histlh2bp; Hist2h2bb; Hist2h2be; Histlhlc; Rpa3

A positive net enrichment score indicates that genes over-represented associated with the respective term are up-regulated in the expression dataset. Negative NES indicates the opposite.