Table 2.
Gene targets of L-lactate linked to selected phenotypes by gene set enrichment analysis.
| Phenotype | NES | FDR | Leading core genes |
|---|---|---|---|
| Abnormal NMDA-mediated synaptic currents | 2.10 | 0.03 | Fosb |
| Impaired spatial learning | 2.13 | 0.03 | Fosb |
| Abnormal paradoxical sleep pattern | 2.08 | 0.03 | Fos; Fosb |
| Abnormal sleep pattern | 2.28 | 0.00 | Fos; Fosb; Perl; Per2; Ptchdl; Slcl8a2 |
| Impaired learning | 2.29 | 0.00 | Arx; Fmrl; Fosb; Nr4a2; Syt4; Ptchdl; Tnc |
| Abnormal sleep behavior | 2.14 | 0.03 | Fos; Fosb; Perl; Per2; Ptchdl; Slcl8a2; Foxo3 |
| Abnormal interleukin-4 secretion | 2.09 | 0.03 | Atf3; Cish; Gadd45b; Nfatcl; Nfil3; Dusp4; Rnfl28 |
| Decreased dopamine level | 2.11 | 0.03 | Gpr37; Hipk2; Nr4a2; Perl; Ptgerl; Sstr2; Slcl8a2; Tnc |
| Abnormal tumor necrosis factor level | 2.21 | 0.01 | Ticam; Cebpb; Crebbp; Egrl; Fos; Ier3; Ldlr; Mapkapk2; Mertk; Ncoa3; Nfil3; Npylr; Pcskl; Duspl; Relb; Arid5a; Tnfrsfla; Pde4d; Sh3bp2; Rc3hl; Tbkl; Apba3; Pelil |
| Abnormal fear/anxiety-related behavior | 2.15 | 0.03 | Spred; Adcyap1; Arc; Arx; Bdnf; Crem; Arid3a; Fmr1; Fos; Fosb; Gpr19; Grin2a; Nr4a2; Penk; Dusp1; Rgs2; Slc2a3; Sstr2; Cpeb3; Slc18a2; Git1; Tnc; Npas4; Gpr26; Dcaf10; B3galt2; Park2; Lrrtm1 |
| Hyperactivity | 2.13 | 0.03 | Braf; Adcyapl; Arx; Bdnf; Chrm4; Crem; Fmrl; Fos; Fosb; Ldlr; Nr4a3; Npylr; Nr4a2; Perl; Lrrc4; Rgs4; Slcl2a2; Ptchdl; Gitl; Tnc; Npas4; Sik2; B3galt2; Dnajb9; Vgf; Usp2; Fezf2; Cystml; Adipor2; Ssfa2; Gpr22 |