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. 2018 Oct 10;9:2293. doi: 10.3389/fimmu.2018.02293

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Copyright © 2018 Knuhr, Langhans, Nyenhuis, Viertmann, Kildemoes, Doenhoff, Haas and Schramm.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-IL-4 abrogated the inhibitory effect of IPSE/alpha-1-triggered basophil-derived IL-4. Release of IL-1β (A) and IL-6 (B) from monocytes co-cultured with autologous basophils without (black bars) or with anti-IL-4 antibodies (gray bars) or with anti-IgG/M (bars with pattern) as control antibody. Inhibition of both IL-1β and IL-6 from LPS-activated monocytes was abrogated by anti-IL-4, while anti-IgG/M had no effect on the inhibition. Data were normalized to the maximum release following LPS activation (100%). Data are presented as mean ± SEM, n = 4 for anti-IL-4 and n = 2 for anti-IgG/M. Statistics were performed by two way ANOVA multiple comparison test; ^* = significance “LPS + additions (IL-4, basophils, basophils + IPSE)” vs. “LPS alone”; ^*p < 0.05, ^**p < 0.01, ^****p < 0.0001.