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. 2018 Oct 17;38(42):8943–8955. doi: 10.1523/JNEUROSCI.0347-18.2018

Table 3.

Anatomical correlates of baseline PANS and SANS activitya

Anatomical region Cluster volume (mm3) x y z Maximum T score β
RSA
    Left ventral anterior insulab 1312 −41 12 −15 5.41 0.79
    Left inferior temporal lobeb 448 −32 2 −36 4.96 0.59
    Right parahippocampal gyrus 320 15 11 −30 4.50 0.63
    Left parahippocampal gyrusb 168 −14 8 −26 4.28 0.68
SCL
    Left inferior temporal gyrusb,c 6120 −51 −21 −27 6.57 0.77
    Left temporal poleb 1528 −33 9 −50 5.02 0.72
    Right fusiform gyrusb 1200 27 −15 −41 5.05 0.69
    Left precentral gyrus 1160 −41 −18 59 4.31 0.75
    Left dorsal mid-insulab 1088 −36 14 15 7.08 0.61
    Left orbitofrontal cortexb 1080 −21 18 −16 4.71 0.65
    Left orbitofrontal cortexb 1080 −18 47 −21 5.34 0.67
    Right orbitofrontal cortexb 912 26 21 −11 5.16 0.54
    Right frontal poleb 880 8 71 14 5.77 0.81
    Right frontal pole 776 −15 69 −11 5.38 0.67
    Left parahippocampal gyrusb 712 −11 −8 −35 5.60 0.79
    Right middle frontal gyrusb 672 50 14 51 6.20 0.89
    Left superior frontal gyrus 600 −17 41 51 4.65 0.81
    Right postcentral gyrus 584 23 −30 74 4.25 0.76
    Right precentral gyrusb 496 44 −20 60 4.30 0.69
    Left precuneus 424 −17 −41 71 4.94 0.70
    Left frontal poleb 424 −38 56 9 4.30 0.66
    Left hypothalamus 424 −8 −5 −9 4.14 0.60
    Left fusiform gyrus 416 −33 −17 −44 4.17 0.73
    Right gyrus rectus 352 9 33 −17 4.16 0.54
    Right precentral gyrus 320 35 −8 62 4.75 0.80
    Left fusiform gyrus 304 51 −11 −29 4.33 0.60
    Left inferior parietal lobe 280 −47 −50 54 4.29 0.73
    Right superior frontal gyrusb 280 23 57 36 5.16 0.67
    Left precentral gyrusb 264 −32 −9 63 4.33 0.77
    Right cerebellumb 232 35 −50 −45 4.02 0.50
    Left pars triangularis 200 −33 33 3 4.09 0.75
    Right inferior parietal lobe 192 48 −42 59 4.38 0.66
    Left supplementary motor area 160 −9 8 65 4.61 0.63

aWhole-brain VBM analyses in patients with bvFTD (controlling for age, sex, and education) revealed that atrophy in many ANS network nodes was associated with lower baseline RSA (n = 21) and SCL (n = 20). MNI coordinates (x, y, z) given for maximum T score for the cluster (cluster size >150 mm3). Results are significant at p < 0.001, uncorrected. To identify the independent neural correlates of PANS and SANS activity, we conducted follow-up VBM analyses when controlling for the opposing autonomic measure (i.e., including SCL as an additional covariate in the RSA VBM analysis and SCL as an additional covariate in the RSA VBM analysis).

bSignificance at p < 0.001, uncorrected, when also controlling for the opposing autonomic measure.

cSignificance at pFWE < 0.05.