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. 2018 Oct 17;38(42):9105–9121. doi: 10.1523/JNEUROSCI.0375-18.2018

Figure 3.

Figure 3.

Downregulation of dorsal determinants and expansion of dLGE markers in the lateral telencephalic neuroepithelium of Dmrt3;Dmrt5 double KO embryos. A, B, Coronal brain sections of E12.5 embryos hybridized with the indicated markers. Arrowheads indicate the region of the PSB. Arrows point to the shifted dorsal limit of ventral markers expressed ectopically in the pallium of the double KO embryos. Open arrows indicate the strongly downregulated expression of Emx1, Emx2, and Ngn2 that remains detectable only in the dorsomedial telencephalon and the absence of Dbx1. Inset in the Isl1 panel of the Dmrt double KO represents a high-magnification view of the boxed region where some Isl1 ectopic staining in the pallium is observed. C, Diagram showing the expression domain of the different markers used in the telencephalon of E12.5 WT embryos and the reduction of the ventral pallium and an expansion of the dLGE domain as observed in Dmrt3−/−;Dmrt5−/−. Scale bar, 200 μm.