Figure 9.

DMRT5 and EMX2 cooperate in telencephalon DV patterning. A, Dorsal views of the head of E12.5 embryos. H&E staining of E12.5 brain coronal sections of the telencephalon, at rostral and caudal levels. Arrows point to the caudomedial cortex of the Dmrt5;Emx2 double mutants, more severely reduced than in single mutants. B, Coronal brain sections of E12.5 embryos processed by ISH with the indicated markers. Arrowheads indicate the region of the PSB. Arrows point to the dorsal limit of Gsx2, Dlx2, and Ascl1 expression, shifted dorsally in the Dmrt5^−/−;Emx2^−/− double KO embryos. *Dramatic reduction of Ngn2 in the cortex of the double KO embryos. Scale bar, 200 μm.