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. 2018 Oct 17;38(42):8956–8966. doi: 10.1523/JNEUROSCI.1332-18.2018

Figure 4.

Figure 4.

Inhibition of PrL neurons projecting to NAc core selectively blocked BDNF-dependent effects on cocaine-seeking. A, Schematic illustration of the viral vector targeting approach and timeline for Experiment 2. B, Representative images of hM4Di-mCherry expression in PrL cortex, as well as CAV-2-Cre-eGFP- and hM4Di-mCherry-expressing terminals in NAc core. Scale bar, 150 μm. C, Acquisition and maintenance of cocaine SA. D, Post-abstinence context-induced relapse test. Left, Active (colored bars) and inactive (white bars) lever presses during the last 3 d of SA. Right, Active and inactive lever presses during 2 h test. *p < 0.05 versus mCherry-PBS. ##p < 0.01 versus mCherry-BDNF. E, Following the PA test, rats extinguished lever pressing over an additional 5 sessions. F, Cue-induced reinstatement test. Left, Active (colored bars) and inactive (white bars) lever presses during the last 2 d of extinction. Right, Active and inactive (white bars) lever presses during 2 h test. *p < 0.05 versus mCherry-PBS. #p < 0.05 versus mCherry-BDNF.