Table 1.
Study Characteristics.
| Systematic Review | Search Strategy | Definitions | Included Studies | Meta-Analysis Performed |
|---|---|---|---|---|
| Chambrone (2011) | Databases: CENTRAL, EMBASE, MEDLINE, OpenSIGLE Other approaches: Reference lists Search period: FER/2010-10-10 Limitations: No limitations mentioned |
Periodontal disease: Slight/mild periodontitis (1-2mm
CAL)Moderate periodontitis (3-4mm CAL)Severe periodontitis
(≥5mm CAL) Outcomes: - LBW: <2500g - PTB: <37wk GA - PTB/LBW: <37wk GA/<2500g |
11 studies (11 prospective cohort): 12,173
women Countries: Fiji; Madagascar; Malaysia; Spain; Sri Lanka; UK; USA (5) |
Y |
| Conde-Agudelo (2008) | Databases: CINAHL, EMBASE, LILACS, MEDLINE,
POPLINE Other approaches: Abstracts international meetings, Contact investigators, Reference lists, Textbooks Search period: FER/2007-06-30 Limitations:No language restrictions |
Periodontal disease: Not reported Outcomes: - PE: Hypertension and proteinuria after 20 weeks GA |
9 studies (2 cohort; 7 CC): 3,912 women Countries: Argentina; Brazil; Colombia; Israel (2); Jordan; Netherlands; Turkey; USA |
Y |
| Corbella (2012a) | Databases: CENTRAL, EMBASE, MEDLINE Other approaches: None Search period:1970/2009-12 Limitations: Language restriction: English; French; German |
Periodontal disease:Not reported Outcomes: - LBW: <2500g - PTB: <37wk GA - Spontaneous abortion/Stillbirth: no definition reported |
26 studies (16 cohort; 10 CC): 23,069
women Countries: Austria; Brazil; Canada; Chile; Fiji; Finland; Hungary (2); Iceland; Jordan; Pakistan; Spain; Sri Lanka; Turkey; UK (2); USA (9); Venezuela |
N |
| Corbella (2012b) | Databases: MEDLINE Other approaches: Hand search, Reference lists Search period: 1965/2011-01 Limitations: Search limited to human studies Language restriction: English; French; German |
Periodontal disease:Not reported Outcomes: - LBW: <2500g - PLBW: no definition reported - PTB: <37wk GA |
17 studies (5 cohort; 11 CC; 1 CS): 10,148
women Countries: Brazil (5); Canada; Chile; France; Hungary (2); South-Korea; Madagascar; Spain; Tanzania; USA (3) |
Y |
| Corbella (2016) | Databases: Cochrane, EMBASE, MEDLINE, SCOPUS Other approaches: Hand search, Reference lists Search period: 1965/2015-01 Limitations: Search limited to human studies No language restrictions |
Periodontal disease:Not reported Outcomes: - LBW: no definition reported - PLBW: no definition reported - PTB: no definition reported |
22 studies (8 cohort; 12 CC; 2 CS): 17,053
women Countries: Brazil (7); Canada; Chile; France; Hungary (2); Italy; South-Korea; Madagascar; Malaysia; Spain (2); Tanzania; USA (3) |
Y |
| Huang (2014) | Databases: EMBASE, PUBMED Other approaches: Reference lists Search period: FER/2013-03 Limitations: Language restriction: English; Chinese |
Periodontal disease: Either the combination of a specific PD
or the presence of CAL or the occurrence of
BOP Outcomes: PE: Blood pressure ≥140/90 mmHg on two separate occasions after 20 weeks GA and ≥1+ proteinuria |
11 studies (3 cohort; 8 CC): 3,916 women Countries: Brazil (3); Canada; Colombia; India (2); South-Korea; Thailand; Turkey; USA |
Y |
| Ide (2013) | Databases: CENTRAL, EMBASE, MEDLINE, WEB OF
SCIENCE Other approaches: Hand search, Reference lists Search period: FER/2012-05 Limitations: No language restrictions |
Periodontal disease: Ranging from gingivitis through
aggressive periodontitisOutcomes: - LBW: <2500g - Miscarriage: no definition reported - PE: maternal hypertension and proteinuria >20wk GA - PTB: <37wk GA - SGA: restricted growth at any given time during gestation - Stillbirth: no definition mentioned - VLBW: <1500g - VPTB: <32wk GA |
38 studies (14 cohort; 22 CC; 2 CS): 25,816
women Countries: Brazil (13); Canada (2); Colombia; Croatia; Finland; France; Hungary; Italy; Japan; Jordan (2); Madagascar; Malaysia; Spain; Thailand; Turkey (3); UK (3); USA (4) |
Y |
| Khader (2005) | Databases: MEDLINE Other approaches: Reference lists Search period: 1966/2002-08 Limitations: Language restriction: English |
Periodontal disease:Not reported Outcomes: - PLBW: <2500g and ≥1 of: GA <37wk, preterm labor or PROM - PTB: <37wk GA |
5 studies (2 cohort; 3 CC): 2,369 women Countries: Chile; USA (4) |
Y |
| Konopka (2012) | Databases: MEDLINE, PUBMED, Polish Medical
Bibliography Other approaches: None Search period: 1966/2010 Limitations: Language restriction: English; German; Polish |
Periodontal disease:Not reported Outcomes: - LBW: <2500g - PLBW: no definition reported - PTB: <37wk GA |
22 studies (6 cohort; 15 CC; 1 CS): 12,047
women Countries: Austria; Brazil (5); Chile; Colombia; Croatia; Germany; Hungary; Jordan; Poland (2); Spain; Sri Lanka; Turkey; UK; USA (4) |
Y |
| Kunnen (2010) | Databases: CINAHL, EMBASE, MEDLINE Other approaches: Reference lists Search period: CINAHL: 2003/2010-08-15 EMBASE: 1974/2010-08-15 MEDLINE:2003/2010-08-15 Limitations: Language restriction: Dutch; English; French; German; Spanish |
Periodontal disease: Not reported Outcomes: - PE: no definition reported |
12 studies (2 cohort; 9 CC; 1 CS): 6,244
women Countries: Argentina; Brazil; Colombia; France; India; Jordan; Netherlands; Thailand; Turkey (2); USA (2) |
N |
| Madianos (2002) | Databases: EMBASE, MEDLINE Other approaches: Hand search, Reference lists Search period: FER/2001-10 Limitations: Search limited to human studies Language restriction: English |
Periodontal disease:Not reported Outcomes: - LBW: <2500g - PLBW: no definition reported - PTB: <37wk GA |
5 studies (1 cohort; 4 CC): 1,588 women Countries: USA (5) |
N |
| Oliveira (2009) | Databases: LILACS, PUBMED, ScIELO Other approaches: None Search period: 1988-10/2007-07) Limitations: Language restriction: English |
Periodontal disease:Not reported Outcomes: - LBW: no definition reported - PTB: no definition reported |
23 Studies (8 cohort; 15 CC): 8,177 women Countries: Brazil (4); Chile; Croatia; Germany; Hungary (2); Saudi Arabia; Spain; Thailand; UK (3); USA (8) |
N |
| Rustveld (2008) | Databases: Cochrane, EMBASE, MEDLINE Other approaches: Reference lists Search period: 1964/2009-08 Limitations: Language restriction: English, German, Spanish |
Periodontal disease:Not reported Outcomes: - PE: no definition reported |
3 studies (1 cohort; 2 CC): 1,305 women Countries: Colombia; Turkey; USA |
N |
| Sanchez (2004) | Databases: MEDLINE, PUBMED Other approaches: Reference lists Search period:1960/2003-05 Limitations: Language restriction: English |
Periodontal disease: Not reported Outcomes: - PLBW: Birth weight less <2500g and GA <37 weeks |
9 studies (3 cohort; 6 CC): 4, 086 women Countries: Chile (2); UK; USA (6) |
N |
| Scannapieco (2003) | Databases: CENTRAL, MEDLINE, MEDLINE Daily
Update Other approaches:Reference lists Search period: FER/2002-09 Limitations: Search limited to human studies |
Periodontal disease:Not reported Outcomes: - LBW: no definition reported - PLBW: no definition reported - PTB: no definition reported |
9 studies (6 CC; 3 CS): 4,383 women Countries: UK; USA (9); Venezuela |
N |
| Sgolastra (2013) | Databases: CDSR, CENTRAL, CINAHL, DARE, ISI WoK, MEDLINE,
Science Direct, SCOPUS Other approaches: Manual search, reference lists Search period: FER/2013-03-24 Limitations: No limitations applied with regard to publication year and language |
Periodontal disease: Not reported Outcomes: - PE: no definition reported |
15 studies (3 cohort; 12 CC): 5,111 women Countries: Brazil (3); Canada; Chile; Japan; South-Korea; Netherlands; India (2); Thailand; Turkey (2); USA (2) |
Y |
| Teshome (2016) | Databases: AMED, CINAHL, Cochrane, EMBASE, Google Scholar,
MEDLINE Other approaches: Reference lists Search period: 2000/2015-09 Limitations: Language restriction: English |
Periodontal disease: Not
reported Outcomes: - LBW: <2500g - PTB: <37wk GA |
10 studies (10 CC): 2,423 women Countries: Argentina; Brazil (2); India (3); Iran; Jordan; Senegal; Tanzania |
N |
| Vergnes (2007) | Databases: BIOSIS, EMBASE, LILACS, MEDLINE.
PASCAL Other approaches: Reference lists Search period: BIOSIS, LILACS, PASCAL:1990/2005-09 EMBASE:1980/2005-09 MEDLINE:1966/2005-09 Limitations: No limitations applied with regard to publication and language; Search limited to human studies |
Periodontal disease: Not reported Outcomes: - LBW: <2500g - PLBW: <37wk GA and/or <2500g - PTB: <37wk GA |
17 studies (4 cohort; 11 CC; 2 CS): 7,151
women Countries: Austria; Brazil (5); Germany; Hungary; Peru; Poland; Saudi Arabia; Sri Lanka; UK; USA (4) |
Y |
| Vettore (2006) | Databases: CAPES thesis, LILACS, PUBMED, ScIELO Other approaches:Reference lists Search period: FER/2005-12-21 Limitations: Search limited to human studies Language restriction: English; Portuguese |
Periodontal disease: Not reported Outcomes: - LBW: no definition reported - PTB: no definition reported |
33 studies (6 cohort; 27 CC): 12,191 women Countries: Austria; Brazil (6); Chile; France; Germany; Hungary; Iceland; Italy; Japan; Poland; Saudi Arabia; Spain; Sri Lanka; Turkey; UK (3); USA (10) |
N |
| Wei (2013) | Databases: EMBASE, PUBMED Other approaches: None Search period: FER/2013-02-10 Limitations: No limitations mentioned |
Periodontal disease: Not reported Outcomes: - PE: no definition reported |
15 studies (2 cohort; 13 CC): 4,711 women Countries: Argentina; Brazil (4); Canada; India; Iran; South-Korea; Netherlands; Thailand; Turkey (2); USA (2) |
Y |
| Wimmer (2008) | Databases: CINAHL, EMBASE, MEDLINE, PASCAL Other approaches: Reference lists Search period: FER/2008-02-01 Limitations: No limitations mentioned |
Periodontal disease:Not reported Outcomes: - BW: no definition reported - GA: no definition reported - IUGR: no definition reported - LBW: no definition reported - PLBW: no definition reported - PTB: no definition reported |
45 studies (23 cohort; 22 CC): 23,780
women Countries: Austria; Brazil (9); Canada; Chile; Croatia; Denmark; Finland (2); Germany; Hungary (2); Iceland; Poland; Saudi Arabia; Spain (2); Sri Lanka; Thailand; Turkey (2); UK (5); USA (11); Venezuela |
N |
| Xiong (2006) | Databases: CINAHL, Current Contents, EMBASE,
MEDLINE Other approaches: Reference lists Search period: 1966-01/2005-03 Limitations: No limitations mentioned |
Periodontal disease:Not reported Outcomes: - BW: no definition reported - GA: no definition reported - LBW: no definition reported - Miscarriage: no definition reported - PE: no definition reported - PTB: no definition reported - SGA: no definition reported |
22 studies (9 cohort; 13 CC): 10,234 women Countries: Austria; Brazil; Canada; Chile; Hungary; Iceland; Saudi Arabia; Senegal; Sri Lanka; Thailand; Turkey (2); UK (3); USA (6); Venezuela |
N |
| Xiong (2007) | Databases: CINAHL, Current Contents, EMBASE,
MEDLINE Other approaches: Reference lists Search period:1966-01/2006-12 Limitations: No limitations mentioned |
Periodontal disease:Not reported Outcomes: - BW: no definition reported - GA: no definition reported - Gestational Diabetes: no definition reported - LBW: no definition reported - Miscarriage: no definition reported - PE: no definition reported - PTB: no definition reported - SGA: no definition reported |
39 studies (13 cohort; 26 CC): amount of participants not
reported Countries: Argentina; Austria; Brazil (4); Canada (2); Chile; Colombia; Croatia; Denmark; Germany; Hungary (2); Iceland; Israel; Saudi Arabia; Senegal; Spain; Sri Lanka; Thailand; Turkey (2); UK (4); USA (10); Venezuela |
N |
AMED, Allied and Complementary Medicine; BOP, bleeding on probing; BW, birth weight; CAL, clinical attachment loss; CC, case control; CDSR, Cochrane Database of Systematic Reviews; CENTRAL, Cochrane Central Register of Controlled Trials; CS, cross sectional; DARE, Database of Abstracts of Reviews of Effects; FER, from earliest records; GA, gestational age; ISI WoK, ISI Web of Knowledge; IUGR, intrauterine growth restriction; LBW, low birth weight; N, no; OpenSIGLE, Open system for Information on Grey Literature in Europe; PD, probing depth; PE, pre-eclampsia; PLBW, preterm low birth weight; PROM, preterm rupture of membranes; PTB, preterm birth; PTB/LBW, combination of preterm birth and/or low birth weight; SGA, small for gestational age; UK, United Kingdom; USA, United States of America; VLBW, very low birth weight; VPTB, very preterm birth; Y, yes.