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. 2018 Nov;24(11):1496–1511. doi: 10.1261/rna.067181.118

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© 2018 Sinha et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society

This article, published in RNA, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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FIGURE 7. — Model for poly(A) polymerase-mediated regulation of RyhB stability. (A) Poly(A) polymerase (PAP I) stabilizes RyhB by facilitating the degradation of 3′ETS^LeuZ (green-colored RNA) through the addition of poly(A) tails, which provide a toe-hold for exoribonucleases. As a result, RyhB is abundant and able to bind and efficiently regulate other mRNA targets (collectively represented by the red-colored RNA), which are subsequently degraded by RNase E along with RyhB. (B) In a strain lacking poly(A) polymerase, 3′ETS^LeuZ (green-colored RNA) accumulates and binds to RyhB leading to RNase E-mediated decay of this sRNA. RyhB levels are thereby reduced, and certain mRNA targets (red-colored RNA) accumulate that would otherwise be negatively regulated by this sRNA.