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. Author manuscript; available in PMC: 2018 Oct 17.
Published in final edited form as: Inorganica Chim Acta. 2017 Nov 22;471:419–429. doi: 10.1016/j.ica.2017.11.029

Table 1.

Drug-like parameters for compounds HL1-HL2.

Compounds cLogP TPSA M.Wt. HBD HBA logBB
HL1 4.08 103.67 294.27 1 7 −0.775
HL2 3.32 111.01 259.22 2 7 −0.999
Lipinski rulesa 5 90 500 5 10 >0.3 to 1.0
a

MW: molecular weight; clogP: calculated octanol-water partition coefficient; HBD: hydrogen-bond donor atoms; HBA: hydrogen-bond acceptor atoms; PSA: polar surface area. (Lipinski, C. A.; Lombardo, F.; Dominy, B. W.; Feeney, P. J. Adv. Drug Delivery Rev. 1997, 23, 3–25; Clark, D. E.; Pickett, S. D. Drug Disc. Today 2000, 5, 49–58).