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. Author manuscript; available in PMC: 2018 Oct 17.
Published in final edited form as: Neurosci Lett. 2018 Apr 19;677:6–13. doi: 10.1016/j.neulet.2018.04.025

Fig. 1.

Fig. 1.

The nonselective nicotinic acetylcholine receptor (nAChR) agonist nicotine showed modest effects on long-term potentiation (LTP) induced by high frequency stimulation (HFS) in the dentate gyrus of hippocampal slices ob-tained from rats. A) The time course of the field EPSP (fEPSP) measurements obtained from dentate gyrus 30min before and 60min after HFS under the control condition (open circle, n = 6) and following the application of 5 μM nicotine (filled circles, n = 7). B) The time course of the field EPSP (fEPSP) measurements obtained from dentate gyrus 30 min before and 60 min after HFS under the control condition (open circle, n = 6) and after the application of 10 μM nicotine (filled circle, n = 7). For both experiments, LTP was induced by HFS consisting of eight trains (each of eight stimuli at 200 Hz, inter-train interval 2 s, indicated by the arrow) with the stimulation current increased during the HFS to elicit the maximum fEPSP amplitude. The periods of nicotine bath appli-cation began 10 min prior to the HFS, as in-dicated by the bars. Bath applications of nico-tine had no effect on the baseline synaptic response. Shown are representative fEPSP traces at the time points (1 and 2) indicated in the time course for baseline (blue) and 60 min following HFS (red). Each trace is an average of 5 consecutive traces before and after HFS under either control conditions or with 5 μM or 10 μM nicotine as indicated. C) Bar charts of the average ( ± SEM) early (first 5 responses after HFS) and late (55-60 min after HFS) potentiation observed under the three conditions shown in panels A & B, left and right graphs, respectively. (For interpretation of the refer-ences to colour in this figure legend, the reader is referred to the web version of this article.)