Figure 2.

Impact of DAA-induced HCV clearance on immune functions: restoration of NK cell activity with increased IFNγ and TNF-α production, leading to APC maturation and proliferation of HCV-specific CD8 T cells. No impact on Treg population is seen following DAA treatment +/- interferon

APC, antigen-presenting cell; DAAs, direct-acting antiviral agents; HCV, hepatitis C virus; IFN, interferon; IL, interleukin; TGF, transforming growth factor; Treg, regulatory T cells; TNF-a, tumor necrosis factor alpha.