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. 2018 Oct 16;19:382. doi: 10.1186/s12859-018-2407-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Evaluation of iSAR for modelling the thermostability of cytochrome P450 variants. Shown are the measured against predicted thermostability values (melting temperature in °C) assessed under the 10-fold cross-validation scheme for the full set of 242 ϖαριαντσ (+), for a training set composed of 80% of the dataset (○) and for a validation set comprising 20% of the variants (□)