Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 16;37:250. doi: 10.1186/s13046-018-0905-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 9 — Overview of pathways for TMZ-POH impaired mitophagic flux. Although TMZ-POH induced mitochondrial fission and autophagosome accumulation which colocalized with mitochondria in the cells significantly, it inclined to block mitophagy flux via inducing lysosomal dysfunction and hampered autophagosome-lysosome fusion due to its downregulation on the small GTPase RAB7A via mevalonate pathway