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. 2018 Oct 15;19:162. doi: 10.1186/s13059-018-1490-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Global reduction of variation in gene expression from the iPSCs to primitive streak state. Box plot of the log₂ variance of expression levels for each gene. Variation in gene expression levels are significantly reduced from iPSCs to primitive streak (P < 10⁻¹⁵ in both species) but not in subsequent time points (P > 0.5 in both species)