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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Nature. 2018 Aug 1;560(7716):70–75. doi: 10.1038/s41586-018-0366-x

Figure 5 |. Functionalization, synthesis, and derivatization of natural products.

Figure 5 |

(a) A series of abundantly available terpenoids serve as competent coupling partners in this dual catalytic protocol, affording complex arylated scaffolds in good yields. Major and minor isomers are denoted. (b) The naturally occurring alkaloid (±)-N-Boc-epibatidine was synthesized in two steps from commercially available materials, and subsequently a small library of analogous compounds was constructed. *>20:1 r.r., >20:1 d.r.; acyclopropane carbonyl chloride employed as electrophilic coupling partner.