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. Author manuscript; available in PMC: 2019 Aug 20.
Published in final edited form as: Angew Chem Int Ed Engl. 2018 Jul 18;57(34):10888–10893. doi: 10.1002/anie.201804667

Figure 4.

Figure 4.

a) Human telomeric sequences wtTel26, wtTel24, and wtTel23, and their folding topologies. b,c) 1H NMR titration of EPI in K+ with wtTel24, (b) and wtTel23, (c), with the signature T-imino peak of the EPI-hybrid-2 complex marked by asterisk. d) CD titration spectra of EPI with wtTel26 in Na+ solution. e) Taq DNA polymerase stop assay using a DNA template containing a wt human telomeric sequence (bottom) showing EPI can induce telomeric G4 formation. Left 4 lanes are sequencing reactions.