Table 6. Comparison between random biopsy and targeted biopsy.

	Random biopsy	Targeted biopsy for index lesion
Total cores	5825 cores	1666 cores
Median number of cores per patient (range)	10.0 cores (0–20)	2.0 cores (1–8)
Cancer positive cores	495 cores	426 cores
Positive for any cancer per core	8.5% (495/5825 cores)	25.6% (426/1666 cores)	p<0.001
Proportion of clinically insignificant cancer cores in all cancer positive cores	48.3% (239/495 cores)	31.9% (136/426 cores)	p<0.001
Median cancer core length (range)	2.0 mm (0.2–17)	5.0 mm (0.16–19)	p<0.001
Positive for clinically significant cancer per patient	14.9% (91/609 patients)	20.7% (130/629 patients)	p=0.009
	Positive only with random biopsy	Positive only with targeted biopsy
Clinically significant cancer	1.6% (10/629 patients)	10.5% (66/629 patients)	p<0.001