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The mRNA expression of class I HDACs negatively correlates with CRP, ESR, and DAS28 levels. The correlations between the mRNA expression levels of class I HDACs and RA disease characteristics were determined by using the Spearman test and are shown for (a) C-reactive protein (CRP), (b) erythrocyte sedimentation rate (ESR), and (c) disease activity score (DAS28).
