Figure 4.

Seipin loss-of-function. We are proposing 4 different general models that usually happen with frequency under seipin loss-of-function. (a) Seipin loss-of-function through silencing or knockout in adipogenic models. Adipocyte maturation and TG synthesis are impaired, and ER stress was not found. (b) Seipin loss-of-function through mutations in adipogenic models. Adipocyte maturation and TG synthesis are impaired, ER stress was positively found, and there is a lack of information about the lipolysis situation. (c) Seipin loss-of-function through silencing or knockout in nonadipogenic models. TG synthesis was increased, lipolysis is impaired, and ER stress was positively found; (d) seipin loss-of-function through mutations in nonadipogenic models. TG synthesis was increased, and there is a lack of information about ER stress and lipolysis. (b) and (d) are the most representative situations of Berardinelli-Seip congenital lipodystrophy (BSCL) type 2. Positive symbols represent a process that is usually increased, while the negative symbols represent the opposite. The interrogation symbol represents a process that needs to be studied further. Pieces of the illustrations are from the SMART website [40].