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. 2018 Oct 17;13:56. doi: 10.1186/s13024-018-0287-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Nrf1 conditional knockout by Rho-iCre causes severe photoreceptor degeneration. (a–f) H&E staining of retinal sections from wildtype (a, c, and e) and Nrf1^f/f;Rho-iCre (b, d, and f) at 6 weeks, 8 weeks, and 5 months old. (g–l) Immunostaining of wildtype (g, i, and k) and Nrf1^f/f;Six3-Cre (h, j, and l) retinal sections with anti-rhodopsin and anti-cone arrestin antibodies at 6 weeks, 8 weeks, and 5 months old. (m) The number of rows of photoreceptor nuclei in wildtype and Nrf1^f/f;Rho-iCre. Scale bars: 20 μm. OS: outer segment. IS: inner segment. ONL: outer nuclear layer. INL: inner nuclear layer. GCL: ganglion cell layer. WT: wildtype