Table 2.
Top 10 GO terms relevant to 488 downregulated genes in E13.5 Nrf1f/f; Six3-Cre retinas
| Rank | GO Category | GO ID | GO Term | Number of Focused Genes | P Value | FDR |
|---|---|---|---|---|---|---|
| 1 | GOTERM_BP_FAT | GO:0030182 | nervous system development | 156 | 1.70E-39 | 6.96E-36 |
| 2 | GOTERM_BP_FAT | GO:0048666 | neurogenesis | 126 | 1.80E-35 | 3.80E-32 |
| 3 | GOTERM_BP_FAT | GO:0031175 | neuron differentiation | 114 | 1.40E-34 | 2.00E-31 |
| 4 | GOTERM_BP_FAT | GO:0048667 | generation of neurons | 119 | 8.00E-34 | 8.40E-31 |
| 5 | GOTERM_BP_FAT | GO:0000904 | neuron projection development | 91 | 6.90E-33 | 5.80E-30 |
| 6 | GOTERM_BP_FAT | GO:0048812 | neuron development | 99 | 7.00E-33 | 4.90E-30 |
| 7 | GOTERM_BP_FAT | GO:0007409 | neuron projection morphogenesis | 68 | 5.00E-29 | 3.00E-26 |
| 8 | GOTERM_BP_FAT | GO:0030030 | cell morphogenesis involved in neuron differentiation | 62 | 5.50E-26 | 2.90E-23 |
| 9 | GOTERM_BP_FAT | GO:0019226 | axonogenesis | 55 | 2.70E-25 | 1.30E-22 |
| 10 | GOTERM_BP_FAT | GO:0048858 | cell projection organization | 99 | 1.40E-24 | 5.90E-22 |
| 1 | GOTERM_CC_FAT | GO:0030424 | axon | 54 | 4.00E-27 | 1.30E-24 |
| 2 | GOTERM_CC_FAT | GO:0045202 | synapse | 57 | 5.30E-23 | 8.90E-21 |
| 3 | GOTERM_CC_FAT | GO:0043025 | neuronal cell body | 58 | 1.40E-22 | 1.60E-20 |
| 4 | GOTERM_CC_FAT | GO:0043005 | neuron projection | 51 | 5.70E-22 | 4.80E-20 |
| 5 | GOTERM_CC_FAT | GO:0016020 | membrane | 243 | 9.40E-16 | 6.00E-14 |
| 6 | GOTERM_CC_FAT | GO:0030425 | dendrite | 46 | 1.90E-15 | 1.10E-13 |
| 7 | GOTERM_CC_FAT | GO:0010469 | postsynaptic density | 31 | 1.10E-14 | 1.70E-12 |
| 8 | GOTERM_CC_FAT | GO:0030054 | cell junction | 53 | 1.80E-13 | 7.50E-12 |
| 9 | GOTERM_CC_FAT | GO:0043195 | terminal bouton | 21 | 1.10E-12 | 4.10E-11 |
| 10 | GOTERM_CC_FAT | GO:0030426 | growth cone | 24 | 1.80E-12 | 6.10E-11 |
| 1 | GOTERM_MF_FAT | GO:0008092 | cytoskeletal protein binding | 52 | 2.40E-10 | 2.40E-07 |
| 2 | GOTERM_MF_FAT | GO:0022836 | gated channel activity | 26 | 6.10E-08 | 2.70E-05 |
| 3 | GOTERM_MF_FAT | GO:0005216 | ion channel activity | 29 | 2.60E-07 | 7.50E-05 |
| 4 | GOTERM_MF_FAT | GO:0022838 | substrate-specific channel activity | 29 | 4.90E-07 | 1.10E-04 |
| 5 | GOTERM_MF_FAT | GO:0015631 | tubulin binding | 23 | 7.60E-07 | 1.30E-04 |
| 6 | GOTERM_MF_FAT | GO:0005261 | cation channel activity | 23 | 1.20E-06 | 1.80E-04 |
| 7 | GOTERM_MF_FAT | GO:0022803 | passive transmembrane transporter activity | 29 | 2.00E-06 | 2.50E-04 |
| 8 | GOTERM_MF_FAT | GO:0015267 | channel activity | 29 | 2.00E-06 | 2.50E-04 |
| 9 | GOTERM_MF_FAT | GO:0019905 | syntaxin binding | 12 | 7.10E-06 | 7.80E-04 |
| 10 | GOTERM_MF_FAT | GO:0017075 | syntaxin-1 binding | 7 | 1.10E-05 | 1.00E-03 |
GO gene ontology, FDR false discovery rate