Table 1.
Changes in patient and BIA variables over time
| T0 | T1 | T2 | Mean Slope (change per day) |
P | |
|---|---|---|---|---|---|
| Patient Variables | |||||
| Actual body weight, kg | 57.4 [57.0] (33.0–100.0) | 58.9 [57.0] (37.7–96.0) | 59.7 [60.0] (37.5–95.0) | 0.02 | < 0.01 |
| Body Mass Index, kg/m2 | 21.2 [21.1] (12.7–39.1) | 21.7 [21.4] (15.4–37.5) | 22.0 [21.7] (15.4–37.1) | 0.01 | < 0.01 |
| Oral calorie intake, kCal | 597 [600] (0–1500) | 904 [1000] (0–2550) | 959 [1000] (0–2550) | 4.18 | < 0.01 |
| Oral protein intake, g/day | 21.1 [20.0] (0–50) | 32.2 [35.0] (0–110) | 34.5 [40.0] (0–90) | 0.15 | < 0.01 |
| PG-SGA category, % | A: 0% | NA | A:8% | NA | < 0.01 |
| B: 48% | B:48% | ||||
| C: 52% | C:44% | ||||
| Karnofsky PS | 67.4 [70.0] (50–90) | NA | 72.5 [70.0] (50–90) | NA | < 0.01 |
| ECOG PS | 1.3 [1] (0–2) | NA | 1.2 [1.0] (0–2) | NA | 0.09 |
| Albumin, g/dL | 3.4 [3.5] (1.9–4.5) | NA | 3.5 [3.5] (2.2–4.6) | NA | 0.19 |
| C-reactive protein, mg/L | 16.7 [10.9] (0.4–73.2) | NA | 13.5 [6.9] (0.1–140) | NA | 0.23 |
| mGPS | 1 [1] (0–2) | NA | 0.6 [0] (0–2) | 0.01 | |
| 0: 37% | 0: 62% | ||||
| 1: 26% | 1: 14% | ||||
| 2: 37% | 2: 25% | ||||
| BIA Variables | |||||
| Resistance, Ohm | 590.9 [606.0] (401–804) | 586.6 [586.0] (401–898) | 584.0 [607.0] (372–780) | −0.08 | 0.45 |
| Reactance, Ohm | 52.0 [48.0] (19–120) | 51.0 [49.0] (20–99) | 51.2 [46.0] (22–116) | − 0.01 | 0.68 |
| Phase Angle, ° | 4.8 [4.8] (2.5–8.1) | 5.0 [4.7] (2.5–11.4) | 5.0 [4.5] (2.3–10.0) | 0.00 | 0.32 |
| Total Body Water, % | 59.4 [59.7] (39.3–85.8) | 58.6 [58.5] (41.3–76.6) | 58.0 [58.2] (41.7–76.4) | −0.02 | 0.04 |
| Extracellular Water, %, | 52.1 [52.2] (25.4–70.7) | 52.1 [52.6] (29.5–69.9) | 52.2 [53.5] (32.3–73.2) | 0.00 | 0.98 |
| Intracellular water, % | 47.9 [47.8] (29.3–74.6) | 48.1 [47.7] (30.1–70.5) | 47.7 [46.3] (26.8–67.7) | 0.00 | 0.89 |
| Fat Mass, % | 23.3 [23.2] (−7.1–50.8) | 24.1 [24.6] (0.5–48.4) | 25.8 [24.3] (1.6–76.9) | 0.03 | 0.04 |
| Fat Free Mass, % | 74.6 [76.6] (49.2–86.9) | 76.0 [75.4] (51.6–101.2) | 75.0 [75.7] (52.5–98.4) | 0.01 | 0.52 |
| Muscle Mass, % | 44.0 [39.2] (25.3–75.4) | 43.2 [40.0] (19.5–120.7) | 42.1 [38.9] (23.5–81.3) | − 0.02 | 0.37 |
All values are expressed as mean [median] (range), or percentage as indicated
T0: at start of HPN; T1: 60 days after the start of HPN; T2: 90 days after the start of HPN
NA Not applicable, BIA Bioelectrical impedance analysis, BMI Body mass index, ECM Extracellular mass, BCM Body cell mass, PS Performance status, ECOG Eastern cooperative oncology group, mGPS Modified Glasgow prognostic score, PG-SGA Patient-generated subjective global assessment; Category A = well-nourished; Category B = suspected malnutrition or moderate malnutrition; Category C = severely malnourished