Table 2.
Changes in patient and BIA variables over time by PG-SGA at T0
| PG-SGA at T0 | T0 | T1 | T2 | Mean Slope (change per day) |
P | |
|---|---|---|---|---|---|---|
| Patient Variables | ||||||
| Actual body weight, kg | B | 60.2 [57.5] (39.0–100.0) | 62.3 [59.6] (41.5–96.0) | 62.8 [60.0] (43.5–95.0) | 0.03 | 0.01 |
| C | 54.9 [56.5] (33.0–85.5) | 55.7 [56.4] (37.7–83.0) | 56.8 [58.5] (37.5–80.0) | 0.02 | 0.02 | |
| Body Mass Index, kg/m2 | B | 22.0 [21.2] (14.5–39.1) | 22.8 [21.9] (16.5–37.5) | 23.0 [22.1] (17.2–37.1) | 0.01 | < 0.01 |
| C | 20.4 [20.7] (12.7–29.1) | 20.8 [20.6] (15.4–28.1) | 21.2 [20.7] (15.4–29.7) | 0.01 | 0.02 | |
| Oral calorie intake, kCal | B | 744.7 [800] (0–1500) | 1190.5 [1200] (0–2550) | 1204.2 [1280] (0–2550) | 5.44 | < 0.01 |
| C | 462.4 [500] (0–1300) | 642.1 [600] (0–1700) | 735.3 [600] (0–1900) | 3.03 | < 0.01 | |
| Oral protein intake, g/day | B | 24.8 [25] (0–50) | 40.6 [40] (0–110) | 40.8 [45] (0–90) | 0.19 | < 0.01 |
| C | 17.6 [17.5] (0–50) | 24.6 [25] (0–75) | 28.8 [30] (0–60) | 0.12 | < 0.01 | |
| Karnofsky PS | B | 67.7 [70] (50–90) | NA | 74.5 [80] (50–90) | NA | < 0.01 |
| C | 67.1 [70] (50–80) | NA | 70.6 [70] (50–90) | NA | 0.1 | |
| ECOG PS | B | 1.3 [1] (0–2) | NA | 1.0 [1] (0–2) | NA | < 0.01 |
| C | 1.4 [1] (1–2) | NA | 1.3 [1] (0–2) | NA | 0.82 | |
| Albumin, g/dL | B | 3.4 [3.5] (1.9–4.5) | NA | 3.7 [3.7] (2.8–4.4) | NA | 0.02 |
| C | 3.4 [3.5] (1.9–4.4) | NA | 3.4 [3.3] (2.2–4.6) | NA | 0.70 | |
| C-reactive protein, mg/L | B | 17.7 [10.5] (0.4–71) | NA | 17.3 [4.0] (0.1–140) | NA | 0.41 |
| C | 15.7 [12.2] (0.9–73.2) | NA | 10.1 [7.2] (0.1–56.5) | NA | 0.11 | |
| mGPS | B | 1 [1] (0–2) | NA | 0.6 [0] (0–2) | NA | 0.07 |
| C | 1 [1] (0–2) | NA | 0.6 [0] (0–2) | NA | 0.10 | |
| BIA Variables | ||||||
| Resistance, Ohm | B | 560.0 [550.0] (401–720) | 573.5 [586.0] (401–722) | 567.3 [602.0] (407–698) | 0.10 | 0.42 |
| C | 619.0 [625] (402–804) | 598.4 [594] (405–898) | 599.1 [610.0] (372–780) | −0.24 | 0.12 | |
| Reactance, Ohm | B | 45.4 [42.0] (19–118) | 46.2 [42.6] (20–69) | 44.8 [42.0] (23–72) | 0.00 | 0.88 |
| C | 58.0 [53.0] (23–120) | 55.5 [52.0] (25–99) | 57.1 [51.5] (22–116) | − 0.01 | 0.69 | |
| Phase Angle, ° | B | 4.5 [4.2] (2.5–7.5) | 4.6 [4.5] (2.5–6.2) | 4.5 [4.4] (2.3–6.3) | 0.00 | 0.82 |
| C | 4.8 [4.8] (2.5–8.1) | 5.0 [4.7] (2.5–11.4) | 5.0 [4.5] (2.3–10.0) | 0.00 | 0.30 | |
| Total Body Water, % | B | 59.5 [59.5] (39.3–76.6) | 57.2 [58.1] (41.3–72.8) | 56.9 [56.5] (42.0–72.0) | −0.03 | < 0.01 |
| C | 59.4 [60.1] (40.3–85.8) | 59.8 [60.0] (43.7–76.6) | 58.9 [59.0] (41.7–76.4) | 0.00 | 0.74 | |
| Extracellular Water, %, | B | 54.1 [56.1] (25.4–70.7) | 53.8 [53.8] (44.9–69.9) | 54.4 [54.4] (44.2–73.2) | 0.00 | 0.89 |
| C | 50.4 [49.1] (31.7–68.5) | 50.5 [50.5] (29.5–69.2) | 50.2 [51.5] (32.3–71.3) | 0.00 | 0.93 | |
| Intracellular water, % | B | 45.9 [43.9] (29.3–74.6) | 46.6 [46.3] (30.1–55.1) | 45.6 [45.6] (26.8–55.8) | 0.00 | 0.95 |
| C | 49.6 [51.0] (31.5–68.3) | 49.5 [49.6] (30.8–70.5) | 49.5 [48.0] (28.7–67.7) | 0.00 | 0.89 | |
| Fat Mass, % | B | 23.8 [25.4] (4.6–50.8) | 26.2 [26.9] (0.5–48.4) | 28.5 [29.1] (1.6–76.9) | 0.05 | 0.02 |
| C | 22.8 [22.7] (−7.3–45.0) | 22.1 [20.5] (1.2–45.4) | 23.4 [21.6] (3.3–43.0) | 0.00 | 0.78 | |
| Fat Free Mass, % | B | 74.4 [74.5] (49.2–86.9) | 73.8 [73.1] (51.6–99.5) | 73.2 [72.0] (52.2–98.4) | −0.01 | 0.401 |
| C | 75.0 [77.4] (55.0–85.4) | 77.9 [79.6] (54.6–101.2) | 76.6 [78.5] (57.0–96.7) | 0.02 | 0.09 | |
| Muscle Mass, % | B | 42.6 [37.7] (25.7–144.6) | 38.8 [36.9] (27.3–64.5) | 38.2 [35.6] (24.2–79.9) | −0.05 | 0.20 |
| C | 45.2 [44.8] (25.3–98.1) | 47.3 [44.6] (19.5–120.7) | 45.6 [42.0] (23.5–81.3) | 0.01 | 0.69 | |
| ECM/BCM Index, % | B | 1.6 [1.6] (−0.4–3.5) | 1.6 [1.5] (0.4–3.5) | 1.7 [1.5] (0.3–4.0) | 0.00 | 0.82 |
| C | 1.3 [1.2] (0.3–3.8) | 1.3 [1.3] (−0.1–3.7) | 1.3 [1.2] (0.2–3.7) | 0.00 | 0.69 | |
All values are expressed as median [median] (range), or percentage as indicated
T0: at start of HPN; T1: 60 days after the start of HPN; T2: 90 days after the start of HPN
BIA Bioelectrical impedance analysis, PG-SGA Patient-generated subjective global assessment; Category A = well-nourished; Category B = suspected malnutrition or moderate malnutrition; Category C = severely malnourished; NA Not applicable, PS Performance status, mGPS Modified Glasgow prognostic score