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Lysosome is impaired in PICK1−/− mice. (a, b) Lungs were harvested 24 h post-CLP. Representative Western blot images and statistical analysis of LAMP1 and cathepsin B in PICK1−/− mice. (c, d) Immunofluorescence and statistical analysis of LAMP1 in PICK1−/− mice post-CLP (magnification, 200x). Results represent the mean ± SEM (n = 6/group). ∗P < 0.05 vs. sham-operated group in WT mice; #P < 0.05 vs. sham-operated group in PICK1−/− mice.
