Table 2.
CKR expression across patient aetiology
| Group | Cytokine expression: M () | ||||
|---|---|---|---|---|---|
| TNFa:IL10 | IFNg:IL10 | IL-10 | TNFa | IFNg | |
| (ratio) | (ratio) | (%) | (%) | (%) | |
| RIF | 63.6 (54.0) | 16.7 (21.8) | 0.80 (0.87) | 44.9 (49.8) | 15.3 (17.3) |
| RPL | 54.8 (62.6) | 20.1 (23.0) | 0.95 (0.93) | 55.2 (53.2) | 18.2 (21.2) |
| Other | 68.4 (72.0) | 21.8 (23.4) | 0.60 (0.71) | 42.2 (48.4) | 13.7 (15.6) |
| Sig. (P) | 0.086 | 0.470 | 0.027* | 0.036* | 0.315 |
Mean baseline intracellular cytokine ratios and percentage expression in the study group (n = 134), stratified by patient aetiology. ANOVA demonstrates no significant difference in baseline stimulated intracellular cytokine expression or ratios between the populations. Only patients with elevated ratios met study inclusion criteria. RIF patients presented with repeated implantation failure (no pregnancy following at least 2 transfers of good quality embryos). RPL are patients with recurrent pregnancy loss. “Other” refers to secondary infertility patients with features of RIF/RPL, not meeting the strict criteria for either group. *indicates statistical significance to P < 0.05