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. 2018 Oct 2;9:1126. doi: 10.3389/fphar.2018.01126

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Copyright © 2018 Guo, Xie, Li, Yuan, Zhang, Hu, Luo, Yu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antidepressant-like behaviors of RE in CRS mice. (A) Total distance in OFT. (B) Entries in center in OFT. (C) Distance in center in OFT. (D) Time in center in OFT. (E) Immobility duration in TST. (F) Immobility duration in FST. Data were shown as mean ± SEM. ^∗P < 0.05, ^∗∗P < 0.01 vs. CON; ^#P < 0.05, ^##P < 0.01 vs. CRS. n = 12 per group. CON, CRS and RE + CRS represent the control group, the group of chronic restraint stress, and the treatment group of rosemary extracts pretreatment plus chronic restraint stress, respectively.