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. 2018 Oct 17;6:105. doi: 10.1186/s40478-018-0617-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Illustrated location of Makurazaki city and the family trees of family A and B. a Geographical illustration of Japan. Makurazaki is a small city in the Kagoshima prefecture, located in the southernmost tip of Kyushu island. b Family trees of the two families harboring p.R1441H in LRRK2 mutation and living in Makurazaki city. Parkinson’s disease is shown as black and schizophrenia is shown as half black and half white. W/W = wildtype, W/M = heterozygous of c.4322G > A, M/M = homozygous of c.4322G > A. Diagonal line denotes deceased individuals. Asterisk represents autopsied cases