Table 6.
Joint associations of serum ALT and SUA with NAFLD prevalence
| Group | Cases/n (%) | Model 1 | Model 2 | ||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | ||
| Total (n = 7569) | |||||||
| Low ALT + low SUA | 1500/6269 (82.8) | 1 | |||||
| Low ALT + elevated SUA | 411/840 (11.1) | 3.22 | 2.77–3.74 | < 0.001 | 1.94 | 1.61–2.34 | < 0.001 |
| Elevated ALT + low SUA | 232/364 (4.8) | 5.34 | 4.27–6.67 | < 0.001 | 2.99 | 2.17–4.11 | < 0.001 |
| Elevated ALT + elevated SUA | 86/96 (1.3) | 26.75 | 13.85–51.65 | < 0.001 | 9.15 | 4.31–19.40 | < 0.001 |
| Men (n = 3126) | |||||||
| Low ALT + low SUA | 613/2482 (79.4) | 1 | |||||
| Low ALT + elevated SUA | 187/408 (13.1) | 2.90 | 2.33–3.61 | < 0.001 | 1.99 | 1.53–2.59 | < 0.001 |
| Elevated ALT + low SUA | 119/184 (5.9) | 4.87 | 3.54–6.71 | < 0.001 | 2.78 | 1.81–4.25 | < 0.001 |
| Elevated ALT + elevated SUA | 48/52 (1.7) | 30.68 | 10.97–85.77 | < 0.001 | 10.75 | 3.56–32.46 | < 0.001 |
| Women (n = 4443) | |||||||
| Low ALT + low SUA | 887/3787 (85.2) | 1 | |||||
| Low ALT + elevated SUA | 224/432 (9.7) | 3.48 | 2.83–4.28 | < 0.001 | 2.00 | 1.55–2.58 | < 0.001 |
| Elevated ALT + low SUA | 113/180 (4.1) | 5.55 | 4.06–7.58 | < 0.001 | 3.18 | 1.99–5.08 | < 0.001 |
| Elevated ALT + elevated SUA | 38/44 (1.0) | 20.60 | 8.68–48.90 | < 0.001 | 7.96 | 2.83–22.39 | < 0.001 |
Elevated ALT: ALT > 40 U/L; Elevated SUA: Men: > 420 μmmol/L, Women: > 360 μmmol/L
Low ALT: ALT ≤ 40 U/L; Low SUA: Men: ≤ 420 μmmol/L, Women: ≤ 360 μmmol/L
Model 1: adjusted for age and sex (only for all participants)
Model 2: adjusted for age, sex (only for all participants), BMI, history of cardiovascular related diseases, DBP, AST, TG, TC, HDL and FPG