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. 2018 Oct 10;11:367. doi: 10.3389/fnmol.2018.00367

FIGURE 1.

FIGURE 1

Nerve fiber layer (NFL) in the retina of an adult cichlid fish (SL 6 cm). (a) Sections from different retinal regions as indicated by the arrows starting at the overview image demonstrate the increase in thickness of the NFL from the peripheral region (left) to the region close to optic nerve head (right). Müller cell processes labeled with GFAP (red) pass through the NFL and form endfeet at the interface to the vitreous. Müller cells express aquaporin-4 (AQP4, green) in higher concentrations at these endfeet. Nuclei are labeled with Draq5. (b) Freeze fracture replica of Müller cell endfeet showing some orthogonal arrays of particles known to consist of AQP4, left inset. The right inset shows an overview, the black boxes indicate locations of higher power views. ONL, outer nuclear layer; INL, inner nuclear layer; GCL, ganglion cell layer; scale bars in (a) are 20 μm, in the overview image 500 μm, in (b) 100 nm.