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. 2018 Oct 10;11:367. doi: 10.3389/fnmol.2018.00367

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Copyright © 2018 Garcia-Pradas, Gleiser, Wizenmann, Wolburg and Mack.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Double-immunostains for the tight junction proteins (green) claudin-3 (a) and claudin-19 (b) and for the adaptor protein ZO-1 (red, a,b). The nerve fiber layer (NFL) shown at high magnification in the right images, is strongly positive for both claudin antibodies. Immunoreactivity for ZO-1 was also detected in the NFL, as well as in the outer limiting membrane (OLM). In the NFL, claudin and ZO-1 stains largely overlap with the claudins showing more continuous label strands often but not always running parallel to nerve fibers. Scale bar 20 μm for low power, 5 μm for high power images.