Table 2.

group	effector	agonist	antagonist	subtype	PAMs	NAMs
group I	Gq, PLC/PKC, PI3K/Akt, mTOR ERK, PLD, PKA, NMDAR, eCB	DHPG, CHPG, quisqualate	MCPG, AIDA	mGlu1	Ro 67–7476	JNJ16259685
				mGlu5	CDPPB, VU29, VU0409551	MPEP, MTEP, fenobam
group II	Gi/o, inhibition of adenylyl cyclase, modulation of K+ and Ca2+ channels	DCG-IV, LY354740, LY379268	LY341495	mGlu2	BINA, LY487379
				mGlu3		ML337
group III	Gi/o, inhibition of adenylyl cyclase, modulation of K+ and Ca2+ channels	L-AP4, LSP4–2022	CPPG	mGlu4	PHCCC
				mGlu7	AMN082 (allosteric agonist)	ADX71743
				mGlu8	DCPG (orthosteric agonist)