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. 2018 Oct 10;9:2341. doi: 10.3389/fimmu.2018.02341

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Copyright © 2018 Yin, Liu, Wang, Ma, Lei, Zhang, Fu, Fu, Hu, Ding, Han, Xu, Shang and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of TIGIT limits the production of IFN-γ by NK cells. (A) A representative flow cytometry plot showing the different percentages of IFN-γ producing NK cells after stimulation with rIL-12 + rIL-15 + rIL-18 for 24 h in HC and HIV-infected individuals. The IFN-γ expression was gated according to an isotype control. (B) Comparison of the function of NK cells from HIV-infected (n = 8) and HC (n = 8) groups, based on their IFN-γ production on stimulation with rIL-12 + rIL-15 + rIL-18. (C) A representative flow cytometry plot showing the different percentages of IFN-γ producing TIGIT⁺ and TIGIT⁻ NK cells from HIV-infected individuals after stimulation with rIL-12 + rIL-15 + rIL-18 for 24 h. (D) Paired comparisons of IFN-γ producing TIGIT⁺ and TIGIT⁻ NK cells from HIV-infected individuals after stimulation with rIL-12 + rIL-15 + rIL-18 for 24 h (HIV: n = 11; HC: n = 12). (E) Analysis of the correlation between the percentage of TIGIT⁺ NK cells and the percentages of IFN-γ producing NK cells from HIV-infected individuals (n = 16). Mann-Whitney U tests were used for comparisons between two groups. The Wilcoxon matched-pairs signed-rank test was used for paired-group comparisons. The Spearman's rank test was employed for correlation analyses. p < 0.05 was considered significant.