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. 2018 Oct 10;9:2341. doi: 10.3389/fimmu.2018.02341

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Copyright © 2018 Yin, Liu, Wang, Ma, Lei, Zhang, Fu, Fu, Hu, Ding, Han, Xu, Shang and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between the expression of CD155 on CD4⁺ T cells and IFN-γ production by NK cells from HIV-infected individuals. (A) Gating strategy used to identify the CD4⁺ T cells. Single cells were gated using the forward scatter area (FSA) and forward scatter height (FSH) (P1), then live cells were gated by Live/Dead (BV510). Lymphocytes were gated according to forward scatter/side scatter properties (FSC/SSC) (P2). CD4⁺ T cells were identified from the CD3⁻CD4⁺ gate. A representative flow cytometry plot showing the expression of CD155 on CD4⁺ T cells in HIV-infected and HC individuals. (B) Comparison of the percentages of CD155 expressing CD4⁺ T cells between HIV-infected (n = 18) and HC (n = 13) groups. (C) A representative flow cytometry plot showing production of IFN-γ in NK cells after treatment with 20 μg/mL anti-human CD155 antibody or purified mouse IgG (as a negative control) from HIV-infected individuals; the production of IFN-γ was gated according to an isotype control. (D) Paired comparison of the production of IFN-γ by NK cells after treatment with 20 μg/mL anti-human CD155 antibodies or purified mouse IgG (as a negative control) from HIV-infected individuals (n = 8). The Mann-Whitney U test was used for comparisons between two groups. The Wilcoxon matched-pairs signed-rank test was used for paired-group comparisons. p < 0.05 was considered significant.