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. 2018 Oct 10;9:1275. doi: 10.3389/fphys.2018.01275

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Copyright © 2018 Nandi, Shahshahan, Shang, Kutty, Boska and Mishra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-133a mimic treatment improves systolic dysfunction of Akita. (A) 2D cardiac performance analysis-MR tracking of left ventricle using long-axis MRI. The global longitudinal strains were recorded. (B) Analyses of cardiac percentage ejection fraction by long-axis MRI. (C) Representatives of short-axis and long-axis images of the heart. Values are represented as mean ± SD, N = 4–5 per group. Two-tailed, unpaired Student’s t-test was used for statistical analysis. P < 0.05 is considered statistically significant.