Table 1.
Selection of recent protection/treatment studies using bnAbs
| BnAb delivery | Epitope | System | References |
|---|---|---|---|
| Adeno-associated virus (AAV) vectored PGT121 | High mannose patch | Humanized mice | [118] |
| Passive infusion of 3BNC117 and 10-1074 | CD4bs High mannose patch |
Non-human primates | [121] |
| Passive infusion of a Tri-specific mix | CD4bs MPER Apex |
Non-human primates | [125] |
| Passive infusion of VRC01 | CD4bs | Humans (phase I) | [126] |
| Passive infusion of VRC01 | CD4bs | Humans phase 1 | [127] |
| Passive infusion of VRC01 | CD4bs | Humans phase 1 | [119] |
| Passive infusion of 3BNC117 | CD4bs | Humans phase 2a | [128] |
| Passive infusion of 3BNC117 and 10-1074 | CD4bs High mannose patch |
Humans phase 1b | [120] |