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. 2018 Oct 17;18:160. doi: 10.1186/s12935-018-0662-4

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — RNAi was utilized to silence CLDN2 expression in osteoblast line. a Western blotting was utilized to examine the effects of silencing CLDN2 and the activation of the Ras/Raf/MEK/ERK signaling pathway in the osteoblast line. b The corresponding statistical analysis of the activation of the Ras/Raf/MEK/ERK signaling pathway. c The wound healing assay was utilized to detect the migration ability of the osteoblast line in vitro. d The transwell chamber method was utilized to detect the impact of CLDN2 silencing on the invasive ability of cells in vitro. e The corresponding statistical analysis of invaded cells. **P < 0.01 compared with the scramble group