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. 2018 Oct 17;18:160. doi: 10.1186/s12935-018-0662-4

Fig. 4.

Fig. 4

RNAi was utilized to silence CLDN2 expression in osteoblast line. a Western blotting was utilized to examine the effects of silencing CLDN2 and the activation of the Ras/Raf/MEK/ERK signaling pathway in the osteoblast line. b The corresponding statistical analysis of the activation of the Ras/Raf/MEK/ERK signaling pathway. c The wound healing assay was utilized to detect the migration ability of the osteoblast line in vitro. d The transwell chamber method was utilized to detect the impact of CLDN2 silencing on the invasive ability of cells in vitro. e The corresponding statistical analysis of invaded cells. **P < 0.01 compared with the scramble group