Table 2.

Comparative semi‐quantitative analysis of tissue injuries among the three cases

	Case 1 (45 yo, F)	Case 2 (56 yo, F)	Case 3 (49 yo, M)
Brain weight (g)	1,060 g	975 g	1,560 g
Disease duration (years)	6	12	2
Cerebral cortex
Neuronal loss/Gliosis	++	+++	±
Spongiform change	±	+	±
Cerebral white matter
Myelin loss/pallor	±	+++	+
Basal ganglia
Neuronal loss/Gliosis	±	+	±
Spongiform change	±	+	±
Hippocampus
Neuronal loss/Gliosis	±	+	±
Spongiform change	±	±	±
Thalamus
Neuronal loss/Gliosis	±	++	±
Spongiform change	±	+	±
Brain stem
Myelin loss/pallor (pyramidal tract)	+++	+++	±
Cerebellar cortex
Neuronal loss/Gliosis	±	±	±
Spongiform change	±	±	±
Cerebellar white matter
Myelin loss/pallor	±	±	+
Spinal cord
Myelin loss/pallor (pyramidal tract)	+++	+++	NA
Myelin loss/pallor (posterior column)	±	+++	NA

yo, years old; M, male; F, female; NA, not available; ±, none or few (minimal); +, mild; ++, moderate; +++, severe.