Figure 4.

One‐micrometer thick toluidine blue‐stained representative cross sections (a) of regenerating sciatic nerves from Tr^J control mice and treated with pyruvate (PYR) at 20 weeks. An apparent increase in the small myelinated fibers in regenerating nerves from PYR treated group is present. Composite histograms showing myelinated fiber distribution in the regenerating sciatic nerves (b) from Tr^J mice at 20 weeks post‐PYR therapy showing an increase in the subpopulation of axons <4 μm in diameter in pyruvate group compared to PBS‐control. G ratio distribution of fibers (c) in the regenerating sciatic nerves from Tr^J mice showing a shift toward increased percent of fibers with smaller G ratio (thicker myelin) in the PYR group