Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 10;9:2319. doi: 10.3389/fimmu.2018.02319

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Chiodetti, Sánchez Vallecillo, Dolina, Crespo, Marin, Schoenberger, Allemandi, Palma, Pistoresi-Palencia, Morón and Maletto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The nanostructured formulation elicits long-lasting humoral response with a single-dose immunization. C57BL/6 mice were immunized on day 0 with OVA/CpG-ODN or OVA/CpG-ODN/Coa-ASC16. On day 147 after immunization, mice were intraperitoneally challenged with OVA. Plasma samples were collected at different time points for determination of OVA-specific antibodies titers by ELISA. (A) Kinetics in plasma of OVA-specific IgG. (B) OVA-specific IgG2c on days 140 (pre-challenge) and 154 (post-challenge) after immunization. The data show the mean ± SEM of individual values (4 mice/treatment group in each experiment) and are representative of two independent experiments performed. ^***p < 0.001, n.s., not significant.