Table 1.
Patient Demographics of the Analytic Cohort
| Covariate | All Patients n = 2,116,163 |
Patients With 2 Malignancies n = 170,865 |
Patients With 1 Malignancy n = 1,945,298 |
P |
|---|---|---|---|---|
| Age at diagnosis of first malignancy, y | <.0001 | |||
| 18–35 | 65,765 (3.11) | 1097 (0.6) | 64,670 (3.3) | |
| 36–50 | 315,219 (14.9) | 11,621 (6.8) | 303,598 (15.6) | |
| 51–65 | 743,755 (35.2) | 56,270 (32.9) | 687,485 (35.3) | |
| 66–80 | 783,457 (37.0) | 87,586 (51.3) | 695,871 (35.8) | |
| ≥80 | 207,965 (9.8) | 14,291 (8.4) | 193,674 (10.0) | |
| Marital status | <.0001 | |||
| Single | 237,754 (11.2) | 14,897 (8.7) | 222,857 (11.5) | |
| Married/domestic partner | 1,282,229 (60.6) | 109,923 (64.3) | 1,172,306 (60.3) | |
| Divorced/widowed/separated | 445,631 (21.1) | 34,732 (20.3) | 410,899 (21.1) | |
| Unknown | 150,549 (7.1) | 11,313 (6.6) | 139,236 (7.2) | |
| Race/ethnicity | <.0001 | |||
| White | 1,749,143 (82.7) | 146,323 (85.6) | 1,602,820 (82.4) | |
| Black | 203,106 (9.6) | 15,727 (9.2) | 187,379 (9.6) | |
| Other | 132,734 (6.3) | 8695 (5.1) | 124,039 (6.4) | |
| Unknown | 31,180 (1.5) | 120 (0.1) | 31,060 (1.6) | |
| Sex | <.0001 | |||
| Male | 1,096,043 (51.8) | 107,097 (62.7) | 988,946 (50.8) | |
| Female | 1,020,120 (48.2) | 63,768 (37.3) | 956,352 (49.2) | |
| % Bachelor’s degree, quartile | <.0001 | |||
| 1st | 535,710 (25.3) | 42,926 (25.1) | 492,784 (25.3) | |
| 2nd | 532,701 (25.2) | 43,455 (25.4) | 489,246 (25.2) | |
| 3rd | 506,193 (23.9) | 39,001 (22.8) | 467,192 (24.0) | |
| 4th | 541,559 (25.6) | 45,483 (26.6) | 496,076 (25.5) | |
| Median household income, quartile | <.0001 | |||
| 1st | 512,048 (24.2) | 40,572 (23.8) | 471,476 (24.2) | |
| 2nd | 530,670 (25.1) | 42,938 (25.1) | 487,732 (25.1) | |
| 3rd | 536,631 (25.4) | 44,570 (26.1) | 492,061 (25.3) | |
| 4th | 536,814 (25.4) | 42,785 (24.0) | 494,029 (25.4) | |
| Y of diagnosis | <.0001 | |||
| 1992–1996 | 344,153 (16.3) | 45,783 (26.8) | 298,370 (15.3) | |
| 1997–2000 | 385,229 (18.2) | 41,503 (24.3) | 343,726 (17.7) | |
| 2001–2004 | 672,300 (31.8) | 53,467 (31.3) | 618,833 (31.8) | |
| 2005–2008 | 714,481 (33.8) | 30,112 (17.6) | 684,369 (35.2) | |
| Primary site | <.0001 | |||
| Prostate | 595,385 (28.1) | 57,946 (33.9) | 537,439 (27.6) | |
| Breast | 491,223 (23.2) | 29,194 (17.1) | 462,029 (23.8) | |
| Lung | 174,431 (8.2) | 8296 (4.9) | 166,135 (8.5) | |
| Colorectal | 275,715 (13.0) | 22,679 (13.3) | 253,036 (13.0) | |
| Non-Hodgkin lymphoma | 108,266 (5.1) | 9499 (5.6) | 98,767 (5.1) | |
| Bladder | 112,207 (5.3) | 15,571 (9.1) | 96,636 (5.0) | |
| Melanoma | 124,587 (5.9) | 9563 (5.6) | 115,024 (5.9) | |
| Endometrial | 90,242 (4.3) | 7298 (4.3) | 82,944 (4.3) | |
| Kidney | 70,945 (3.4) | 6839 (4.0) | 64,106 (3.3) | |
| Thyroid | 73,162 (3.5) | 3980 (2.3) | 69,182 (3.6) | |
| Grade | <.0001 | |||
| Well differentiated | 224,008 (10.6) | 19,677 (11.5) | 204,331 (10.5) | |
| Moderately differentiated | 823,121 (38.9) | 74,927 (43.9) | 748,194 (38.5) | |
| Poorly differentiated | 485,378 (22.9) | 34,769 (20.4) | 450,609 (23.2) | |
| Undifferentiated | 47,044 (2.2) | 3708 (2.2) | 43,336 (2.2) | |
| Unknown/not applicable | 536,612 (25.4) | 37,784 (22.1) | 498,828 (25.6) | |
| Stage | <.0001 | |||
| In situ or localizeda | 1,330,915 (62.9) | 116,668 (68.3) | 1,214,247 (62.4) | |
| Regional | 396,089 (18.7) | 25,650 (15.0) | 370,439 (19.0) | |
| Distant | 127,696 (6.0) | 3852 (2.3) | 123,844 (6.4) | |
| Unstaged | 195,826 (9.3) | 13,824 (8.1) | 182,002 (9.4) | |
| Unknown | 65,637 (3.1) | 10,871 (6.4) | 54,766 (2.8) |
a
Includes cases of prostate cancer coded as “localized/regional.”