Table 3.
Risk of Developing a Second Primary Malignancy Estimated From a Cox Proportional Hazards Model
| Females | Males | |||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Site | ||||
| Prostate | - | Referent | ||
| Bladder | 1.66 (1.60–1.72) | <.0001 | 1.88 (1.84–1.92) | <.0001 |
| Breast | Referent | 1.69 (1.53–1.87) | <.0001 | |
| Colorectal | 1.17 (1.14–1.20) | <.0001 | 1.42 (1.39–1.45) | <.0001 |
| Endometrial | 1.31 (1.27–1.34) | <.0001 | - | |
| Lung | 1.22 (1.17–1.26) | <.0001 | 1.44 (1.39–1.49) | <.0001 |
| Melanoma | 1.37 (1.31–1.43) | <.0001 | 1.69 (1.63–1.75) | <.0001 |
| Non-Hodgkin lymphoma | 2.88 (2.69–3.07) | <.0001 | 2.70 (2.58–2.83) | <.0001 |
| Renal cell cancer | 1.53 (1.46–1.60) | <.0001 | 1.86 (1.80–1.92) | <.0001 |
| Thyroid | 1.29 (1.23–1.34) | <.0001 | 1.73 (1.63–1.84) | <.0001 |
| Age at diagnosis of first malignancy, y | ||||
| 18–35 | Referent | Referent | ||
| 36–50 | 2.34 (2.18–2.52) | <.0001 | 3.28 (2.89–3.71) | <.0001 |
| 51–65 | 4.67 (4.35–5.02) | <.0001 | 8.80 (7.79–9.94) | <.0001 |
| 66–80 | 7.13 (6.63–7.65) | <.0001 | 15.10 (13.37–17.04) | <.0001 |
| ≥80 | 6.20 (5.75–6.69) | <.0001 | 15.24 (13.47–17.23) | <.0001 |
| Race | ||||
| White | Referent | Referent | ||
| Black | 1.04 (1.01–1.07) | .007 | 1.13 (1.11–1.15) | <.0001 |
| Other | 0.83 (0.80–0.86) | <.0001 | 0.79 (0.76–0.81) | <.0001 |
| Unknown | 0.05 (0.04–0.08) | <.0001 | 0.04 (0.04–0.05) | <.0001 |
| Marital status | ||||
| Married/domestic partner | Referent | Referent | ||
| Divorced/widowed/separated | 1.09 (1.07–1.11) | <.0001 | 1.05 (1.03–1.07) | <.0001 |
| Single | 1.06 (1.03–1.09) | <.0001 | 0.97 (0.94–0.99) | .0032 |
| Unknown | 1.04 (1.00–1.08) | .0509 | 1.04 (1.01–1.06) | .0029 |
| Grade | ||||
| Well differentiated | Referent | Referent | ||
| Moderately differentiated | 1.05 (1.03–1.08) | <.0001 | 1.01 (0.99–1.04) | .3413 |
| Poorly differentiated | 1.12 (1.09–1.15) | <.0001 | 1.06 (1.04–1.09) | <.0001 |
| Undifferentiated | 1.20 (1.13–1.27) | <.0001 | 1.11 (1.06–1.16) | <.0001 |
| Unknown/not applicable | 1.01 (0.98–1.04) | .4398 | 0.93 (0.90–0.96) | <.0001 |
| Stage | ||||
| Localized and in situ | Referent | Referent | ||
| Distant | 0.96 (0.92–1.01) | .1312 | 0.84 (0.80–0.88) | <.0001 |
| Regional | 1.01 (0.99–1.03) | .1687 | 0.97 (0.95–0.99) | .0075 |
| Unknown | 0.01 (0.00–0.02) | .9196 | 1.05 (1.03–1.08) | <.0001 |
| Unstaged | 0.52 (0.49–0.55) | <.0001 | 0.69 (0.66–0.72) | <.0001 |
| % Bachelor’s degree, quartile | ||||
| 1st | 1.14 (1.10–1.18) | <.0001 | 1.12 (1.09–1.15) | <.0001 |
| 2nd | 1.08 (1.05–1.12) | <.0001 | 1.07 (1.04–1.09) | <.0001 |
| 3rd | 1.04 (1.01–1.07) | .0029 | 1.01 (0.99–1.03) | .1811 |
| 4th | Referent | Referent | ||
| Median income, quartile | ||||
| 1st | 0.90 (0.87–0.93) | <.0001 | 0.96 (0.93–0.98) | .0012 |
| 2nd | 0.91 (0.88–0.94) | <.0001 | 0.93 (0.91–0.95) | <.0001 |
| 3rd | 0.97 (0.95–0.99) | .0265 | 0.99 (0.98–1.01) | .5978 |
| 4th | Referent | Referent |
Abbreviations: 95% CI, 95% confidence interval; HR, hazard ratio.