FIGURE 1:

The SNCA locus with association results and linkage disequilibrium. The top and bottom left panels show regional Manhattan plots for 3 rounds of stepwise conditional analysis in the discovery data and degree of linkage disequilibrium (LD) with the lead single nucleotide polymorphism (SNP). Note the lack of SNPs in high LD with rs356182 and the different scale of the y-axis across plots. At the bottom right, the pattern of LD between these SNPs as well as the 2 proposed functional variants rs356165 and rs356168 is illustrated as an LD plot. The numbers represent r² values, and darker shade represents higher D′. The figure was made using LocusZoom (locuszoom.org) and Haploview (www.broadinstitute.org/haploview). [Color figure can be viewed at www.annalsofneurology.org]