FIGURE 3:

Increasing susceptibility across SNCA risk score quintiles. The figure shows odds ratios of risk quintiles incorporating the independent effect of 3 significant association signals at the SNCA locus in a combined score, assessed by logistic regression. Odds ratios are shown relative to the first quintile. Error bars represent 95% confidence intervals. Note that score performance was assessed in the replication dataset, which is independent from the discovery data that were used to generate the allele weights for the scoring algorithm.