TABLE 1.
Datasets Included in the Study
| Dataset | PD Patients | Controls | Genotyping Array | |||||
|---|---|---|---|---|---|---|---|---|
| n | Female, % | Age at Onset, yr, Mean (SD) | Diagnostic Criteria | n | Female, % | Age at study, yr, Mean (SD) | ||
| Discovery | ||||||||
| IPDGC NeuroX28 | 5,542 | 35.5 | 61 (13) | UKPDBB or neurologist diagnosis | 5,866 | 44.2 | 64 (15) | Illumina NeuroX |
| Replication | ||||||||
| phs000089.v3.p2, NINDS3 | 916 | 40.3 | 58 (13) | UKPDBB | 801 | 58.1 | 59 (16) | Illumina HumanHap550 BeadChip |
| phs000126.v1.p1, CIDR45 | 864 | 40.0 | 60 (16) | Modified UKPDBBa | 856 | 60.2 | 55 (13) | Illumina HumanCNV370 BeadChip |
| phs000196.v2.p1, NGRC9 | 1,972 | 32.4 | 58 (12) | UKPDBB | 1,984 | 61.3 | 70 (14) | Illumina HumanOmni1_Quad |
| Oslo46 | 474 | 36.3 | 56 (11) | Modified UKPDBBa | 464 | 42.5 | 62 (11) | Illumina Infinium OmniExpress24 |
| PPMI47 | 314 | 32.2 | 60 (8) | PPMI criteria | 166 | 35.5 | 61 (11) | Illumina NeuroX |
| Finland48 | 386 | 45.9 | 55 (6) | Neurologist diagnosis | 493 | 78.9 | 92 (4) | Illumina 660W or HumanCNV370 BeadChip |
| Germany3 | 741 | 39.7 | 56 (12) | UKPDBB | 944 | 57.5 | 47 (12) | Illumina HumanHap550 BeadChip |
| Harvard Biomarker Study | 541 | 34.6 | 66 (10) | Neurologist diagnosis | 473 | 61.7 | 79 (9) | Illumina NeuroX |
| Parkinson’s Disease Biomarker Program49 | 543 | 38.5 | 64 (9) | Neurologist diagnosis | 284 | 51.1 | 62 (11) | Illumina NeuroX |
| Spain50 | 210 | 35.2 | 67(11) | UKPDBB | 171 | 55.0 | 58 (14) | Illumina NeuroX |
| Sum replication | 6,961 | 6,636 | ||||||
| Total | 12,503 | 12,502 | ||||||
Age data were missing for 2% of patients and 0.3% of controls in the replication sample.
a
Modified UKPDBB criteria allow for affected first-degree relatives.
CIDR = Center for Inherited Disease Research; IPDGC = International Parkinson Disease Genomics Consortium; NGRC = NeuroGenetics Research Consortium; NINDS = National Institute of Neurological Disorders and Stroke; PD = Parkinson disease; PPMI = Parkinson’s Progression Marker Initiative; SD = standard deviation; UKPDBB = United Kingdom Parkinson’s Disease Brain Bank criteria.