TABLE 3.

LD and Functional Prediction Scores of Statistical Top Hit and Proposed Causal SNPs

SNP	r2 with rs356182 1000 Genomes/Present Study	LINSIGHT Score	Phred-Scaled CADD
rs356182	—	10.0	10.68
rs356165	0.76/0.81	0.055	4.58
rs356168	0.49/0.55	0.096	5.87

Note the moderate LD values indicating that rs356182 would not be a likely top hit merely by virtue of tagging any of the other proposed functional SNPs. Prediction tools favor a hypothesis of rs356182 as functional in itself.

CADD = Combined Annotation and Depletion algorithm; LD = linkage disequilibrium; SNP = single nucleotide polymorphism.