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. Author manuscript; available in PMC: 2018 Oct 17.
Published in final edited form as: Cell Rep. 2018 Sep 25;24(13):3367–3373.e4. doi: 10.1016/j.celrep.2018.08.075

Figure 3. NK Cell Suppression of GC Responses Has Consequences for Somatic Hypermutation.

Figure 3.

(A) Total number of mutations in unique VH186.2 BCR sequences isolated from spleens of control or α-NK1.1 mice day 12 post-immunization with NP-KLH in alum. Data were analyzed via Mann-Whit-ney with median displayed; n = 5–6 mice/group.

(B) The proportion of unique VH186.2 sequences from (A) containing the W33L mutation in control and α-NK1.1 mice.

(C) The frequency of either replacement or silent mutations at all positions within the VH186.2 sequence between control or α-NK1.1 mice. Experiments were repeated 2 or 3 times.