Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 17;4(10):eaat4751. doi: 10.1126/sciadv.aat4751

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

PMC Copyright notice

Fig. 3 — (A) Detailed timeline of the experiments. (B) Mechanical nociceptive thresholds immediately after nicotine escalation and 48 hours into withdrawal. During withdrawal, a significant decrease in hyperalgesia thresholds was observed compared with baseline (BSL) thresholds (n = 11; t = 11.9, df = 10, P < 0.01). (C) In PBS-treated animals, a significant decrease in hyperalgesia thresholds was observed compared with baseline thresholds at 24 hours into withdrawal (n = 11; t = 13.89, df = 10, P < 0.01) and 48 hours into withdrawal (n = 11; t = 9.96, df = 10, P < 0.01) but not during nicotine self-administration. (D) In NicA2-J1–treated rats, a decrease in hyperalgesia thresholds was observed at 24 hours into withdrawal (n = 11; t = 13.89, df = 10, P < 0.05). *P < 0.05, **P < 0.01.