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. Author manuscript; available in PMC: 2018 Oct 17.
Published in final edited form as: Pharmacol Ther. 2018 Jun 5;190:128–138. doi: 10.1016/j.pharmthera.2018.05.014

Fig. 1.

Fig. 1.

PRL phosphatases are highly homologous. The P-Loop and WPFDD Loop are critical to phosphatase activity. The prenylation motif targets PRLs to the plasma membrane. The polybasic region facilitates PRLs binding to the plasma membrane.