Table IV.
Kyoto Encyclopedia of Genes and Genomes pathway analysis of the dysregulated genes (top 20) identified from mRNA sequencing.
| Description | Count P | -value | Gene upregulated | Gene downregulated | Fold enrichment |
|---|---|---|---|---|---|
| Legionellosis | 4 | 0.02 | ITGB2, EEF1A2, BNIP3 | CXCL2 | 7.11 |
| Regulation of lipolysis in adipocytes | 4 | 0.02 | AQP7, PTGS2 | ADORA1, PIK3R3 | 6.86 |
| Glycolysis/gluconeogenesis | 4 | 0.03 | LDHA, TPI1, PGK1 | LDHC | 5.73 |
| Cysteine and methionine metabolism | 3 | 0.06 | LDHA | SDSL, LDHC | 7.58 |
| Adrenergic signaling in cardiomyocytes | 5 | 0.06 | CACNG6, RAPGEF4, | BCL2, PIK3R3 | 3.29 |
| PPP2R5B | |||||
| Biosynthesis of antibiotics | 6 | 0.07 | LDHA, TPI1, PGK1, RGN | SDSL, LDHC | 2.72 |
| HIF-1 signaling pathway | 4 | 0.08 | VEGFA | TFRC, BCL2, PIK3R3 | 3.92 |
| Insulin resistance | 4 | 0.10 | PPP1R3B, PPP1R3C | PPARGC1A, PIK3R3 | 3.55 |
| Carbon metabolism | 4 | 0.11 | TPI1, PGK1, RGN | SDSL | 3.40 |
| Sphingolipid signaling pathway | 4 | 0.13 | PPP2R5B | ADORA1, BCL2 PIK3R3 | 3.20 |
| VEGF signaling pathway | 3 | 0.13 | VEGFA, PTGS2 | PIK3R3 | 4.72 |
| AMPK signaling pathway | 4 | 0.13 | PFKFB4, PPP2R5B | PPARGC1A, PIK3R3 | 3.15 |
| Insulin signaling pathway | 4 | 0.17 | PPP1R3B, PPP1R3C | PPARGC1A, PIK3R3 | 2.78 |
| Rap1 signaling pathway | 5 | 0.17 | ITGB2, VEGFA, RAPGEF4, | PIK3R3 | 2.29 |
| Biosynthesis of amino acids | 3 | 0.18 | TPI1, PGK1 | SDSL | 3.89 |
| Hepatitis B | 4 | 0.19 | BCL2, TLR3, PIK3R3, IFIH1 | 2.65 | |
| Hematopoietic cell lineage | 3 | 0.22 | MME, CD4 | TFRC | 3.39 |
| Small cell lung cancer | 3 | 0.22 | PTGS2 | BCL2, PIK3R3 | 3.39 |
| Oxytocin signaling pathway | 4 | 0.22 | PTGS2, CACNG6, CAMK1D | PIK3R3 | 2.43 |
Significant values are shown in bold.